Abstract
The determination of homocysteine (Hcy) is important because high levels are associated with a greater risk of developing heart disease or stroke. Herein, an electrochemical sensor of homocysteine was constructed based upon the self-assembly of 6-ferrocenylhexanethiol (FcC6SH) on a MoS2 nanoparticles-modified electrode with a Nafion coating. The sensor showed a favorable electrocatalytic activity for oxidation of homocysteine since 6-ferrocenylhexanethiol acted as a good electron transfer mediator. Moreover, the MoS2 nanoparticles served as modifiers to covalently immobilize FcC6SH and enhance the electrochemical active surface area. Highly sensitive determination of homocysteine was achieved with a linear range from 2.0 to 100 µmol L−1 and a minimum detectable concentration of 0.30 µmol L−1 by chronoamperometry. The constructed sensor was applied to the analysis of immunoglobulin G (IgG) samples with satisfactory results.
Published Version
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