Abstract

Ciclopirox olamine is one of the basic antifungal agents used in medicine. The multiplicity of pharmaceutical and cosmetic preparations containing ciclopirox olamine causes the need for quick methods to assay it. In this work, the author proposes a method of assaying ciclopirox olamine using BDDE electrode modified with overoxidized polypyrrole (OPPy-BDDE). The work involved the analysis of optimum conditions of BDDE electrode modification. Ciclopirox olamine displayed a well-defined irreversible oxidation peak at the potential of +0.68 V (versus SCE electrode). The analysis of recorded currents depending on the scan rate showed their diffusion character. The pH values and the kinds of electrolyte were optimized using cyclic voltammetry. The optimization of characteristic parameters in the SWV method was conducted in Britton-Robinson buffer with pH 6.98. A linear range of ciclopirox olamine determination was obtained in the concentration range from 6.95 × 10−6 to 6.02 × 10−5 mol/L with the limit of detection of 2.02 × 10−6 mol/L and good repeatability (3.63%, n = 6 measurement, c = 2.34 × 10−5 mol/L). The influence of interferents was also tested. The proposed procedure was successfully used to assay the analyte in pharmaceutical preparations. The obtained results were compared with the values obtained with the comparative method. The error of the developed procedure in relation to the pharmacopoeial method did not exceed 2.5%.

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