Electrochemical Determination of Acetaminophen with a FeNi Nanoparticle Reduced Graphene Oxide (rGO) Nanocomposite and Differential Pulse Voltammetry (DPV)

Abstract

Acetaminophen (AP) is one of the most commonly used antipyretics. Accurate and efficient determination of its concentration is of great significance to human health. In this work, FeNi alloy nanoparticles and reduced graphene oxide (rGO) were compounded by an ultrasonic method to obtain FeNi/rGO nanocomposites. The nanocomposites were analyzed by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), and cyclic voltammetry (CV). Due to the catalytic activity of FeNi alloy nanoparticles and the synergy between the high specific surface area and conductivity of reduced graphene oxice (rGO), a FeNi/rGO nanocomposite showed excellent electrocatalysis for acetaminophen determination. With differential pulse voltammetry (DPV) as the analytical method, the linear range for acetaminophen is from 1 to 100 and 100 to 3,000 μM with a limit of detection (LOD) equal to 0.3 μM. Moreover, the sensor also has good reproducibility and selectivity with high recoveries in practical analysis.