Abstract
Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm<sup>2</sup>. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k<sup>0</sup>) was obtained to be 1.332× 10<sup>3</sup> s<sup>-1</sup>. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10<sup>-7</sup> M to 10.0 × 10<sup>-5</sup> M by using DPV and limit of detection of 9.7 × 10<sup>-8</sup> M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.
Highlights
In the last few decades electrochemical methods are most widely studied and accepted for the determination of electroactive compounds in pharmaceutical samples and physiological fluids due to its simple, sensitive, rapid and economical properties [1, 2]
In addition to its antihistamine properties, tripelennamine acts as a weak serotonin reuptake inhibitor (SRI) and dopamine reuptake inhibitor (DRI) [14,15,16,17]
Because of its serotonin reuptake inhibitor (SRI) properties, tripelennamine was used as basis for the development of selective serotonin reuptake inhibitor (SSRI) fluvoxamine (Luvox) [18]
Summary
In the last few decades electrochemical methods are most widely studied and accepted for the determination of electroactive compounds in pharmaceutical samples and physiological fluids due to its simple, sensitive, rapid and economical properties [1, 2]. Electroanalytical chemistry along with the use of oxidation–reduction reactions and other charge-transfer phenomena had its origins eight decades ago It is one of the fundamental sub disciplines of analytical chemistry. Tripelennamine hydrochloride (TPA, Chemical structure as given in Figure 1) is a member of pyridine and ethylenediamine classes. It is first generation antihistamine psychoactive drug as an antipruritic. In addition to its antihistamine properties, tripelennamine acts as a weak serotonin reuptake inhibitor (SRI) and dopamine reuptake inhibitor (DRI) [14,15,16,17]. In view of pharmaceutical importance and biological significance of the drug and to develop a simple, low-cost direct current voltammetric method for the determination of TPA, present work had been carried out. In our experiment slope was 14.96×10-6 μA (Vs-1)-1/2 and area of the electrode was calculated to be 0.0202 cm
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