Electrochemical Detection of Paracetamol by Voltammetry Techniques Using Pure Zirconium Oxide Nanoparticle Based Modified Carbon Paste Electrode

Abstract

The central theme of this work is Synthesis of zirconium oxide nanoparticles (ZrO2NPs) through solution combustion technique as well as their structural and morphological characterization using XRD, SEM and TEM. Electrochemical detection of paracetamol (PA) is described using ZrO2NPs Modified Carbon Paste Electrode (ZMCPE). From the XRD analysis confirms that the particles are crystalline nature and in tetragonal phase, the average particle size found to be 35 nm. From SEM analysis it is observed that, whatever materials formed is porous in nature and these particles were appears to be uniform. HRTEM discloses that, the average particles size in between 30 and 40 nm and SAED pattern shows that crystallinity of the ZrO2NPs. These results are good agreement with the results obtained through XRD. ZNPs was explored for Electrochemical detection and quantification of paracetamol (PA) was performed through cyclic voltammetric and differential pulse voltammetric method at different circumstances like concentration of the analyte, applied potentials and pH. The overpotential for oxidation of paracetamol is reduced, and the response of current improved significantly on the ZrO2NPs/MCPE (ZMCPE) in assessment through that of BCPE. The Linear calibration curve is found over the range 10 μM to 60 μM, and the LOD is found to be 0.68 μM. The ZMCPE enabled the immediate detection of serotonin, paracetamol and dopamine and with good reproducibility.