Abstract
Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of DIC+, resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM.
Highlights
Was 6-fold higher than a previous study [26]. This result indicates that the micro-ITIES is closest to the recessed microinterface behavior
The voltammetric behavior of ion dibucaine transfer across water|1,6-dichlorohexan at micro-ITIES was investigated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV)
The experimental voltammograms were contributed by both radial and linear diffusions on the forward scan, while a linear diffusion control on the reverse scan. This behavior indicates that the diffusion zone overlap exists, and the micro-ITIES is closest to the recessed microinterface behavior
Summary
Ion transfer via the liquid|liquid interface or the interface between tw electrolyte solutions (ITIES) has captured researchers’ interest in several ch ological applications, such as drug behavior, membrane transport and e
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