Abstract
Composite films of alginic acid–hyaluronic acid and alginic acid–heparin were deposited by electrochemical method for the surface modification of conductive substrates. Obtained films were studied by SEM, thermogravimetric analysis (TGA), differential thermal analysis (DTA) and Fourier transform infrared spectroscopy (FTIR). The deposition yield increased with increasing concentration of hyaluronate and heparin in the alginate solutions. The results of deposition yield measurements coupled with the results of TGA and DTA studies showed the possibility of the formation of deposits of different composition. These results are in a good agreement with the FTIR data, which revealed characteristic adsorption peaks of hyaluronic acid and heparin for the composite films. Film thickness was varied in the range of 0–10 μm by the variation of the deposition time at a constant deposition voltage. Obtained films can be used for the surface modification of biomedical implants with improved biocompatibility.
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