Electrochemical degradation of favipiravir (anti-viral) drug from aqueous solution: optimization of operating parameters using the response surface method

Abstract

ABSTRACT The aim of the current study is to investigate the efficacy of the electro-Fenton process in the degradation of favipiravir drugs from aqueous solutions, which has increased in use as a result of the COVID-19 pandemic. The Response Surface Methodology (RSM) was developed using a Central Composite Design (CCD) in which five independent variables, including Fe2+ concentration, current density, initial FVP concentration, pH, and reaction time, were coded with high and low levels, and the maximum removal percentage of FVP (97.8%) and COD (91.65%) were determined as responses. In the EF process, 530 mg/L H2O2 was produced in-situ by cathodic reduction of O2 in aqueous solution and thus FVP has been successfully oxidized through hydroxyl radicals. The H2O2/Fe2+ ratio was determined to be 0.51 under optimum conditions. At the end of the experiment, the maximum energy consumption was found to be 2.12 kWh per g COD. The FVP was completely mineralized in a very short time by the EF process, according to the LC-MS/MS examination. The EF process followed the pseudo first-order kinetic model with the rate constants of 0.023, 0.016 and 0.006 1/min for pH 2, 3 and 4, respectively. According to the findings of this study, the electro-Fenton process is an effective method for removing FVP from aqueous solutions. To the authors’ knowledge, this is the first study to show the degradation and optimum conditions of FVP in aqueous solution using the electro-Fenton (EF) process.