Abstract
Carboplatin is one of the most prescribed and essential medications for chemotherapy treatment of human cancers. Unfortunately, many patients relapse with carboplatin resistance, making treatment inefficient and cost-intense. The cellular mechanisms of carboplatin-resistance are poorly understood. One suggested mechanism is the inhibition of drug uptake to prevent the intracellular accumulation of the drug. Herein, we present an electroanalytical approach to monitor the consumption of carboplatin by drug-susceptible and drug-resistant ovarian cancer cells. For this purpose, carboplatin was thoroughly characterized by voltammetry and its suitability for physiological bioelectrochemical studies was assessed. Diffusion and adsorption processes of carboplatin were evaluated, its dependence on pH was investigated, and a limit of detection for carboplatin at unmodified Pt electrodes was identified, without the need of expensive and time-intense electrode modification strategies. Our results report the application of voltammetry as a rapid, inexpensive, and sensitive method to quantify drug consumption by cancer cells.
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