Electrochemical Characterization of Amoxycillin, a Broad Spectrum Antibiotic on a Bentonite Host Matrix, Using Cyclic Voltammetry

Abstract

In this paper we report on the redox properties of amoxycillin , a broad spectrum anti biotic. on a bentonite modified working electrode. The CV obtained with ethanol is well defined and quasi reversible suggesting fast electrode kinetics. The oxidation peak in the case of water exhibits a shoulder at 0.195v and a well defined peak at 0.465v with a broad reduction peak approximated at 0.450v. In the case of ethanol, there is a single well defined oxidation peak at 0.480v and a well defined reduction peak at 0.330v. Interaction of amoxycillin with metal cations (co 2+ , pb 2+ , fe 2+ cu 2+ ), amino acids- methionine, leucine arginine and with hydrocortisone and paracetamol was assessed. The results obtained confirm the interactions of amoxil with these chemical substances. The amoxil redox potential is altered or inhibited in certain cases. This is informative given that these substances are commonly used together with amoxil as part of a prescription, notwithstanding the fact that the amino acids are iimportant macromolecules in the human biochemical/physiological system. The UV-vis spectrophotometric analysis showed that, the absorbance of amoxil is a affected by electrolyte solution pH, probably an indication of the latter affecting the extent of conjugation in amoxil.