Abstract
Quaternaryammonium compounds (QACs) are cationic surfactants with broad range applications. They enter into aquatic environment through the discharge of sewage effluents and adversely affect the ecosystem due to toxicity. Modern electrochemical methods have been used for characterization and detoxification of an extensively used QAC, didodecyldimethylammonium bromide (DDAB) in a wide pH range. The diffusion coefficient of DAAB was determined by Randles-Sevcik equation. In acidic conditions the electrochemical reduction of DAAB occurred by two electrons and two protons process. However, in neutral medium the overall reduction of DAAB followed electronation-protonation mechanism involving 3e– and 3H+. Although DDAB is toxic yet it is bestowed with cancer preventing ability. Hence, for getting insights into the under-standing of DAAB anticancer effect, its DNA binding parameters has been evaluated.
Highlights
Surfactants are widely used as household and industrial cleaning agents
Cyclic voltammetric (CV) behavior of didodecyldimethylammonium bromide (DDAB) has been examined in pH range 1 - 13
Where Ipc is the cathodic peak current in amperes, n the number of electrons transferred during the reduction, A the geometric area of the electrode in cm2, c the cathodic charge transfer coefficient, Do the diffusion coefficient in cm2·s–1, n the number of electrons involved in the electrochemical process, Co* the bulk concentration of the oxidant in mol cm-3 and the scan rate in V·s–1
Summary
Surfactants are widely used as household and industrial cleaning agents. They are classified as: cationic, anionic, non-ionic and zwitterionic. Quaternary ammonium compounds (QAC) are the most extensively studied surface active agents They are mainly used as slimicides in swimming pools, antistatic agents in hair conditioners and wetting agents in nasal sprays [1,2]. A variety of techniques has been employed [14,15,16,17,18] for the study of toxicity alleviation and drug-DNA interaction with relative advantages and disadvantages. Most of these suffer from high cost, low sensitivity and procedural complication. Electrochemical techniques were used for the characterization, detoxification and DNA binding studies of DAAB due to their cost effecttivity, high sensitivity and ease of operation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
