Abstract
AbstractThis paper demonstrates a Schiff base i. e. 5‐(diethylamino)‐2‐((2,6‐diethylphenylimino)methyl)phenol (5‐DDMP) that was sensed by DNA biosensor. dsDNA was immobilized onto GCE modified with functionalized multi‐walled carbon nanotubes to prepare a biosensor. The efficiency of dsDNA biosensor was determined and binding of 5‐DDMP with dsDNA was searched by UV‐vis spectrophotometry and differential pulse voltammetry. Molecular docking simulations between 5‐DDMP and dsDNA were explored and as a result, a hydrogen bond and a π‐π contact were observed between 5‐DDMP and deoxyguanosine base (dG22) of the strand B, deoxyadenosine base (dA5) of the strand A, respectively. These studies could be useful for new anticancer drug design and development.
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