Abstract
An investigation of the electrochemical reduction, oxidation, and determination of the monobactam antibiotic, aztreonam (Azm) at different types of electrodes namely: dropping mercury electrode (DME), static mercury drop electrode (SMDE), glassy carbon electrode (GCE), carbon paste electrode (CPE), and modified carbon paste electrode (MCPE) is introduced. The electrode mechanism is found to be comparable to that of the metabolic reaction. Two different techniques were utilized for the drug determination in either aqueous medium or in urine samples, differential pulse stripping voltammetry (DPSV) and Osteryoung square-wave stripping voltammetry (OSWSV). These allow the drug determination in a concentration range as low as 5×10 −8 M after preconcentration for 60 s. Modification of the CPE with gelatin allows better selectivity of the drug in urine matrix. Detection limits of 2×10 −8 M and 8×10 −8 M Azm were achieved in aqueous and urine samples, respectively.
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