Abstract
Fenamic acid and its derivatives were determined in aqueous solution by electrochemical methods on poly-N-acetylaniline glassy carbon electrode (PNAANI/GCE). This is the first general electrochemical method for determination of the fenamates group of NSAIDs. The method is cheap and easily available, which may lead to possible applications in the pharmaceutical industry as its use of NSAIDs are quite common worldwide. Analytical parameters such as the limit of detection (LOD) or the linearity range were ascertained for each compound: fenamic acid (FA) 6.25·10–7 M–3.00·10–5 M with LOD 2.15·10–8 M; mefenamic acid (MFA) 2.50·10–7–6.25·10–6 M with LOD 7.66·10–9 M; flufenamic acid (FFA) 2.50·10–6–9.00·10–6 M with LOD 5.68·10–9 M and tolfenamic acid (TFA) 7.50·10–7–2.25·10–6 M with LOD 3.23·10–9 M. The electrochemical assay was validated by UV–vis spectroscopy. The interaction between conducting polymer (PNAANI) and fenamic acid, which is a parent structure for the analysed group NSAIDs, were studied by quantum mechanical methods by means of the Gaussian 16 package at the DFT-D3 B3LYP/6-311++G** level, with included Grimme dispersion. Theoretical calculations have shown that the most probable structure is that of a fenamic acid dimer surrounded by two fibers of PNAANI, so interactions stabilizing the complex are possible.
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