Abstract
Cyclocytidine (cC) a deaminase-resistant antimetabolic antineoplastic agent and analogue of cytarabine (araC), is studied by polarography and coulometry in buffered aqueous media in the pH range 2–11. The proposed reduction mechanism is an overall four-electron process, similar to the reduction mechanism of araC but without deamination. Some parallelism between the electrochemical behaviour of these drugs and their biological behaviour is found. The kinetics of the hydrolytic transformation of cC to araC are also studied, and the half-life time obtained under physiological conditions (37°C, pH 7.2) is 20 h.
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