Abstract
Electrochemical Behaviors of Methocarbamol at an Acetylene Black-Ionic Liquid Modified Carbon Paste Electrode and its Electrochemical Determination
Highlights
Methocarbamol (MET), 3-(2-methoxyphenoxy)-1,2propandiol-1-carbamate is a central muscle relaxant that is used to treat skeletal muscle spasms and relieve pain and discomfort caused by strains, sprains, and the other muscle injuries for human and the other mammals.[1,2] MET is absorbed from the intestine and widely distributed in all body tissues, especially the liver and the kidney.[3]
The above mentioned experiment results indicated that the presence of acetylene black (AB) and ionic liquid in the modified electrode showed a good electrocatalytic ability to oxidation of MET, which was attributed to the high conductivity, the large surface area of AB16 and the inherent catalytic ability of Ionic liquids (ILs).[32]
The electrochemical behaviors of MET were investigated at the bare carbon paste electrode (CPE), AB/CPE, [BnMIM]PF6/ CPE and AB-[BnMIM]PF6/CPE by cyclic voltammetry (CV) and square wave voltammetric (SWV)
Summary
Methocarbamol (MET), 3-(2-methoxyphenoxy)-1,2propandiol-1-carbamate (structure formula shown in Figure 1.) is a central muscle relaxant that is used to treat skeletal muscle spasms and relieve pain and discomfort caused by strains, sprains, and the other muscle injuries for human and the other mammals.[1,2] MET is absorbed from the intestine and widely distributed in all body tissues, especially the liver and the kidney.[3]. The electrochemical behaviors of 1.0 10–4 mol L–1 MET at the bare CPE, AB/CPE, [BnMIM]PF6/CPE and AB-[BnMIM]PF6/CPE were investigated with the scanning rate of 100 mV s–1 in PBS (pH = 6.8) over the potential range between 0.20 V and 1.25 V by CV (Figure 4.). The oxidation peak potential of MET at AB[BnMIM]PF6/CPE keep almost constant and the oxidation peak current increased significantly by 2.1 times compared with that of CPE, which exhibited a great response of electrocatalytic activity.
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