Abstract
The voltammetric behavior of vardenafil was studied on glassy carbon electrode using cyclic, differential pulse (DPV) and Osteryoung square-wave (OSW) voltammetric techniques. Vardenafil exhibited irreversible anodic waves over the pH range 1.00–12.00 in different supporting electrolytes. The current–concentration plot was rectilinear over the range from 4 × 10 −7 to 2 × 10 −5 M with correlation coefficient of 0.999. The wave was characterized as being irreversible and diffusion-controlled. The developed procedure was successfully applied to the determination of vardenafil in tablets and in spiked human serum. Furthermore, results obtained by the proposed method have been compared with high-performance liquid chromatographic method.
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