Electrochemical behavior of spiroplatin at carbon paste and platinum electrodes

Abstract

AbstractThe voltammetric behavior of the hydrolyzed platinum(II) antitumor drug spiroplatin has been investigated at carbon paste and platinized platinum electrodes. The compound is oxidized to the corresponding platinum(IV) species at positive potentials near the solvent oxidation potential. On reversal of the potential scan, two 2‐electron reduction steps occur on the carbon paste electrode, resulting in formation of platinum metal, as confirmed by scanning electron microscopy. In the presence of chloride, different reduction peaks associated with the formation of chloro structures are observed. These depend on the chloride ion concentration. The oxidation‐reduction steps become more reversible at the platinum electrode. The nature of the oxidized species and the amount of platinum deposit were found to be related to the concentration of free chloride ions. Because the carbon paste electrode has the ability to differentiate the different oxidized forms upon reduction, its use is recommended for studying these compounds.