Abstract
The oxidation of ketoconazole (KC) was investigated by rotating disk electrode voltammetry, cyclic voltammetry, and controlled potential coulometry in chloroform at platinum (Pt), gold (Au), and glassy carbon (GC) electrodes using tetrabutylammonium perchlorate as supporting electrolyte. Based on the electrochemical results obtained, the following possible mechanism was proposed to explain the electrochemical oxidation of KC KC ⇌-e KC·+ -e P P′ A differential pulse voltammetric method at a Pt electrode was developed for the determination of KC from pharmaceutical preparations in the concentration of 3.0×10–6–1.0×10–4 M. The procedure was applied to the determination of KC in its tablets and creams as well as its recovery from blood serum and urine samples.
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