Abstract

The electrochemical reduction of camazepam was investigated by current-sampled direct current polarography, differential pulse polarography, and cyclic voltammetry. Reduction of the drug was carried out in one irreversible, diffusion-controlled step using Britton-Robinson buffers. The half-wave potential for 1.26 × 10 −4 M camazepam at pH 2.7 and 10% methanol-water solutions was −0.823 V (versus Ag/AgCl/3 M KCl). The hydrolysis reaction occurring with camazepam in an acid medium was studied in detail by differential pulse polarography and kinetics parameters were calculated. New methods for the determination of camazepam in commercial preparations and urine are proposed.

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