Abstract
Cu2O@aptamer nanospheres were prepared via a facile one-step synthesis using aptamer as template. The precursor CuSO4 was reduced in the presence of aptamer to form Cu2O@aptamer nanospheres. In comparison with the pristine Cu2O immobilized with aptamer, the resultant Cu2O@aptamer nanospheres exhibit high sensitivity for detecting thrombin. The results showed that the developed electrochemical biosensor based on Cu2O@aptamer nanospheres has a detection limit of 0.01ngmL−1 (0.33pM) within the linear range from 0.1 to 50ngmL−1 toward the thrombin detection. Moreover, excellent selectivity toward interfering proteins, such as IgG, IgE, and BSA, was achieved. The fabricated electrochemical immunobiosensor provides a promising alternative for determining other biological samples.
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