Abstract
AbstractIn this study, the neutral and cationic liposomal formulations of Colistimethate sodium (CMS), an antibiotic for multi‐drug resistant gram‐negative bacteria, were prepared and electrochemical quantification of CMS from these liposomes were achieved. This is the first study of the electrochemical detection of CMS released from liposomes. First, the electrochemical properties of CMS were analysed, then the encapsulation efficiency, and the release kinetic of CMS from liposomes were determined with Differential Pulse Voltammetry (DPV) measurements. In addition, Cyclic Voltammetry were applied to determine oxidation signal of CMS. A higher encapsulation efficiency was found in the cationic liposome compared to the neutral liposome. Moreover, CMS was controlled released from liposomes with zero‐order drug release kinetics.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
