Electrochemical activation and carboxylation of fluorine-containing aromatic imines

Abstract

On the basis of a study of the processes involved in the electrochemical activation of a series of fluorine-containing aromatic imines with and without the presence of carbon dioxide it was shown that the initial stage of such processes is the formation of imine radical-anions, which can both undergo spontaneous transformations and react with CO2 with the formation of fluorine-containing amino acids. A correlation was established between the effects of the electronic structure of the imines on the electrochemical characteristics of their reduction and on the stability of the radical-anions. A relationship was established between the parameters of electrochemical activation of the imines in the presence of CO2 and the yields of the amino acids.