Abstract
In the present paper, the use of a carbon paste electrode modified by meso-tetrakis(3-methylphenyl) cobalt porphyrin (CP) and TiO2 nanoparticles for the determination of levodopa (LD) and carbidopa (CD) was described. Initially, cyclic voltammetry was used to investigate the redox properties of this modified electrode at various scan rates. Next, the mediated oxidation of LD at the modified electrode was described. At the optimum pH of 7.0, the oxidation of LD occurs at a potential about 150mV less positive than that of an unmodified carbon paste electrode. Based on differential pulse voltammetry (DPV), the oxidation of LD exhibited a dynamic range between 0.1 and 100.0μM and a detection limit (3σ) of 69±2nM. DPV was used for simultaneous determination of LD and CD at the modified electrode, and quantitation of LD and CD in some real samples (such as tablets of Parkin-C Fort and Madopar, water, urine, and human blood serum) by the standard addition method.
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