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Abstract
An electrochemical sensor was fabricated and used to simultaneously determine guanine and adenine in DNA. In this work, the poly (2,6-pyridinedicarboxylic acid)/chemically reduced graphene oxide modified glass electrode (PPDA/CRGO/GCE) was constructed. The PPDA/CRGO/GCE was characterized by scanning electron microscopy. The modified electrode displayed greatly improved voltammetric response to guanine (G) and adenine (A). Differential pulse voltammetry (DPV) was used for individual or simultaneous determination of guanine and adenine. The electrode showed good reproducibility with linear ranges of 0.05–4.5μM and 0.1–6.0μM, detection limits of 0.01μM and 0.02μM for guanine and adenine, respectively. The electrochemical method for the measurement of guanine and adenine in calf thymus DNA was also developed and the result was satisfactory.
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