Electrocatalytic Fast and Efficient Multicomponent Approach to Medicinally Relevant Pyrano[3,2-c]quinolone Scaffold

Abstract

‘One-pot’ electrocatalytic fast (3 min) transformation of arylaldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one and malononitrile or methyl cyanoacetate in alcohol in an undivided cell results in the formation of substituted 5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinolones in 85–97% substance yields and 850–970% current efficiency via complex multicomponent process. This novel electrocatalytic chain process opens an effective fast and convenient way to functionalized pyrano[3,2-c]quinolones which are known as pharmaceutical agents for treating disorders responsive to the induction of apotosis, antiproliferation or vascular disruption. This efficient electrocatalytic approach to the pyrano[3,2-c]quinolone scaffold represents novel synthetic concept for multicomponent reactions (MCR) strategy and allows to combine the synthetic virtues of conventional MCR with ecological benefits and convenience of facile electrocatalytic procedure.