Electrocatalytic Behavior and Determination of Amitriptyline Drug with MWCNT@Celllulose Composite Modified Glassy Carbon Electrode.

Aftab Aslam Parwaz Khan

doi:10.3390/ma13071708

Abstract

A novel nanocomposite of cellulose based on multiwalled carbon nanotube (MWCNT) was synthesized by a simple solution mixing–evaporation method. The morphology, thermal investigations, electrocatalytic oxidation of amitriptyline were analyzed at multi-walled carbon/cellulose nanocomposite in detail. The amitriptyline (AMT) drug was electrochemically studied in a phosphate buffer at different pH using the MWCNT/cellulose modified glassy carbon electrode (GCE). As per the linear relationship among AMT along with peak current, differential pulse voltammetry technique has been established for their quantitative pharmaceutical’s determination. The oxidation potential shifted negatively compared to GCE, showing that the MWCNT/cellulose modified electrode had an excellent catalytic activity for the AMT oxidation. The anodic peak current varied linear response with AMT’s concentration in the range of 0.5 to 20.0 μM with a LOD of 0.0845 μM and LOQ of 0.282 μM, respectively. The proposed method was effectively put on the determination of AMT in pharmaceutical and urine samples. This novel methodology is presented here as an example of a complete development methodology for the determination of amitriptyline drug and sensor for use in healthcare fields.

Highlights

Cellulose is considered the most abundantly produced, as well as extensively degraded, polymer in our environment and for harbors one-half of all organic carbon [1]
Carboxymethyl cellulose (CMC) is a derivative of cellulose having a carboxymethyl group that is bound to several hydroxyl organizations
Carboxymethyl cellulose/multiwalled carbon nanotube (MWCNT) nanocomposite was prepared by a simple solution mixingevaporation method

Summary

Introduction

Cellulose is considered the most abundantly produced, as well as extensively degraded, polymer in our environment and for harbors one-half of all organic carbon [1]. Cellulose is a highly crystalline, as well as a high-molecular weight polymer, that is insoluble and infusible in aqueous solvents. Carboxymethyl cellulose (CMC) is one of the essential industrial biopolymers. CMC is a semi-synthetic cellulose’s derivation created by partial substitution of the cellulose’s hydroxyl group by a far more appropriate carboxymethyl group as compared to cellulose [2,3]. CMC is a derivative of cellulose having a carboxymethyl group that is bound to several hydroxyl organizations. The polar carboxymethyl group helps to make cellulose chemically reactive as well as soluble [4,5].

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Conclusion