Abstract
In the present study the hypothalamus of the cat was explored through out by means of the Horsley-Clarke apparatus. Three hundred seventy-five individual diencephalic points were electrically stimulated in 10 animals. The location of each point stimulated by the tip of the electrode was in all cases precisely defined by millimeter coordinates. Histologic verification of the electrode placements was accomplished by sectioning and staining the hypothalamus after each experiment. Ether anesthesia was employed for surgery, on termination of which intravenous curarization with Flaxedil and thorough procaine local anesthesia were given and maintained throughout the experiment. Concentric bipolar electrodes were used. The stimulation of each explored point lasted 30 seconds. The stimulus was a square wave current of 3 milliseconds pulse duration and 100 cycles per second, and did not exceed a maximum of 5 volts. These stimulation parameters were found to be most effective for the production of the changes observed. Continuous electrocardiographic tracings were taken in Lead II, using needle electrodes. A control electrocardiogram was run before each stimu lation, and a period of recovery elapsed before another site in the hypo thalamus was stimulated.
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