Abstract
An electroanalytical method was developed for the direct quantitative determination of paracetamol in tablets based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on born-doped diamond (BDD) electrode using two voltammetric techniques (CV and DPV). The electrochemical measurements performed by cyclic voltammetric (CV) and differential pulse voltammetry (DPV) techniques were carried out using a cathodically pretreated boron-doped diamond electrode in HClO4 and KClO4 electrolytes. HClO4 was then selected for analytical purposes and scan rate studies were also completed. The oxidation of the paracetamol is found to be irreversible and a diffusion-controlled nature of the paracetamol oxidation peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 0 μM to 13.87 μM, with 0.16 μM and 0.55 μM as the detection and quantification limit respectively.
Highlights
Paracetamol (N-acetyl-p-aminophenol) is an effective and important analgesic and antipyretic agent used widely to relieve pain related to arthralgia, neuralgia, headache and cancer [1]
No peak is observed in the absence of paracetamol in the two electrolytes
A simple, sensitive, selective differential pulse voltammetry (DPV) technique for the quantitative determination of paracetamol based on its electrochemical oxidation at born-doped diamond (BDD) electrode was established
Summary
Paracetamol (N-acetyl-p-aminophenol) is an effective and important analgesic and antipyretic agent used widely to relieve pain related to arthralgia, neuralgia, headache and cancer [1]. Large doses, more than 4 g/day, and chronic use of paracetamol or concomitant use with alcohol or other drugs can cause skin rashes, liver disorders, nephrotoxicity and inflammation of the pancreas In this case, the precise determination and control of the paracetamol become vital [3]. Electrochemical sensors have been proven as an inexpensive and simple analytical method with remarkable detection sensitivity, reproducibility and easy to miniaturize rather than other instrumental analysis methods [11] They have been found to have a wide range of applications in clinical, industrial, environmental and agricultural analysis [12]. Its metallic character due to the replacement of some carbons by boron atoms has been shown These properties make BDD suitable for electrochemical studies of analytes with a high oxidation potential [22]. The results obtained are compared with other results with different operating conditions and working electrodes
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