Abstract
An electrochemical sensor for sulfasalazine determination based on molecularly imprinted polymer (MIP) as recognition element has been developed. A sulfasalazine selective MIP and a non-imprinted polymer (NIP) were synthesized and then incorporated in the carbon paste to prepare the modified carbon paste electrodes. Trace amount of sulfasalazine was determined by using differential pulse voltammetry method based on electrochemical reduction of sulfasalazine at the modified electrodes. The MIP based sensor showed high recognition ability of sulfasalazine in comparison with the NIP based sensor. The influence of experimental parameters affecting sensor response such as carbon paste composition, pH, incubation time, potential scan rate and potential amplitude were optimized. Under optimal conditions, the MIP based sensor exhibited good performance for sulfasalazine over the concentration range of 1.0×10−8 to 1.0×10−6molL−1 with a detection limit of 4.6×10−9molL−1 and sensitivity 1.11×107μALmol−1. The MIP based sensor was successfully applied to the determination of sulfasalazine in a commercial pharmaceutical formulation and human serum, offering feasibility and applicability of the sensor to the complex matrices.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
