Electroanalytical determination of acetaminophen using polymerized carbon nanocomposite based sensor

Abstract

Acetaminophen (AC) is one of the most commonly consumed painkillers worldwide and hence its increased use leads to higher concentrations in source water, thus needful its analysis. The voltammetric analysis of AC using the fabricated sensor was presented in this article. The voltammetric sensor based on the poly asparagine modified carbon nanotube and graphene mixed paste electrode (PASMCNTMGPE) was constructed. The constructed electrode unveiled a boosted electrocatalytic activity towards the detection of AC than the unmodified electrode through the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) technique. The Field Emission Scanning Electron Microscopy (FE-SEM) was utilized to verify the morphological feature of the designed electrode. The charge transfer resistance of the designed electrode was studied by electrochemical impedance spectroscopy (EIS). Some of the factors influencing the voltammetric signal of AC such as the number of electropolymerisation cycles and pH were optimized. The redox reaction of AC at the PASMCNTMGPE is a pH-dependent and adsorption-controlled process. The designed electrode yielded a low detection limit (4.10 × 10 −8 M) for AC. In addition, the prepared electrode demonstrated an excellent anti-fouling property, reliability, selectivity, and repeatability. More importantly, the feasibility of the constructed sensor was evaluated by analyzing AC in the pharmaceutical and biological samples.