Abstract
Abstract A simple method to detect and determine 1,3-dimethylxanthine has been proposed by modifying the working electrode with zinc oxide nanoparticles. The electrochemical response of the drug was studied by various voltammetric techniques such as cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. The modified sensor exhibits good response in pH 6.0 phosphate buffer solution. A probable electro-oxidation mechanism was proposed based on relationship between scan rate and potential. The modified surface was characterized by atomic mass spectroscopy (AFM) analysis. Zinc oxide nanoparticles were characterized by X-ray diffraction (XRD) and scanning electronic microscope (SEM). The influence of physic-chemical parameters like scan rate, pH, accumulation time, amount of the modifier and concentration on the voltammetric behavior of an analyte were studied. The linear response in the concentration variation study showed lowest detection limit compared to the earlier reported processes. The current sensor was used to determine drug in pharmaceutical and urine samples with good recovery values.
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