Abstract
This study investigated the effect and mechanism of electroacupuncture (EA) on the contralesional hemisphere in rats with ischemic stroke. EA of 2 Hz was applied on the contralesionally Luoque (BL8) and Tongtian (BL7) acupoints of the scalp to investigate the neurological status and mechanism in ischemia–reperfusion injury rats. The differences in the neurological deficit score and Rotarod test time between days 3 and 15 after reperfusion were significantly lower in the sham group (0.00 (−1.00, 0.00) and 3.53 (−0.39, 7.48) second, respectively) than in the EA group (−4.00 (−4.00, −3.00) and 44.80 (41.69, 54.13) second, respectively, both p < 0.001). The ratio of infarction volume was 0.19 ± 0.04 in the sham group greater than 0.07 ± 0.04 in the EA group (p < 0.001). On day 15, in the cerebral cortex of the lesioned hemisphere, the gamma-aminobutyric acid (GABA)-A/actin ratio in the normal group (1.11 ± 0.36) was higher than that in the sham group (0.38 ± 0.07, p < 0.05) and similar to that in the EA group (0.69 ± 0.18, p > 0.05); the difference between the EA and sham groups was significant (p < 0.05). EA of 2 Hz on the BL8 and BL7 acupoints on the contralesional scalp can improve motor function and also can reduce infarction volume, and this effect of EA, and that GABA-A, plays at least a partial role in ischemia–reperfusion injury rats.
Highlights
As part of stroke epidemiology in southwestern China, an analysis of 16,892 people over 40 years of age revealed that 3.1% of them have had a stroke; of these individuals, 17.1% were found to have risk factors for stroke, such as hypertension, dyslipidemia, and diabetes [1]
Cramer and Moore using functional magnetic image resonance revealed that cortical reorganization along the periphery of the infarct plays a critical role in poststroke sensorimotor functional recovery [8]. e activity of the contralesional motor cortex is vital for poststroke motor function recovery of the paretic limb [9]. e balance of interhemispheric inhibition changes after stroke
Statistical Analysis. e data are represented as median or mean ± standard deviation. e Kruskal-Wallis nonparametric test, with Dunn’s post hoc test, was used for neurological deficit score, Rotarod test, and passive avoidance test. e ANOVA test with Games-Howell post hoc test was used for gamma-aminobutyric acid (GABA)-A, and Tukey’s HSD post hoc test was used for brain-derived neurotrophic factor (BDNF) and PSD-95. p < 0.05 was considered statistically significant
Summary
As part of stroke epidemiology in southwestern China, an analysis of 16,892 people over 40 years of age revealed that 3.1% of them have had a stroke; of these individuals, 17.1% were found to have risk factors for stroke, such as hypertension, dyslipidemia, and diabetes [1]. A clinical trial revealed that the administration of intravenous recombinant tissue plasminogen activator (tPA) within 3 h of ischemic stroke onset can improve clinical outcomes at 3 months, it can increase the incidence of intracerebral hemorrhage [5]. Cerebral edema commonly occurs in the early period after ischemic stroke and is related to the degree of neurological deficit [6]; cerebral blood flow is reduced in the penumbra of the infarct [7]. Cramer and Moore using functional magnetic image resonance revealed that cortical reorganization along the periphery of the infarct plays a critical role in poststroke sensorimotor functional recovery [8]. Erefore, this study investigated the mechanism and effect of EA on the contralesional hemisphere in rats with ischemic stroke. The right MCA of SpragueDawley rats was occluded for 30 min followed by reperfusion to establish an ischemic stroke in rats
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