Abstract
Although acupuncture therapy, as a preventive and therapeutic technique, is low or no risk for some cardiovascular diseases, its role in safeguarding myocardial hypertrophy (MH) has not been clarified. Therefore, this study focused on examining whether electroacupuncture (EA) can alleviate MH by up-regulating tryptophan 5-serotonin (5-HT) metabolism, depressive disorder, and gastrointestinal dysfunction in MH rat models. We evaluated the effect of EA on myocardial ischemia in the ISO-induced myocardial hypertrophy (MH) rat model. Forty SpragueDawley (SD) rats aged 3 months were randomly divided into normal group, model group, EA group, and sham EA group with 10 rats in each group. Heart weight/body weight ratio (HW/BW) and left ventricular weight/body weight ratio (LVW/BW) were used to evaluate the regression of MH. Cardiac pathology was evaluated by ultrastructural observation and hematoxylin and eosin (H&E) staining. Sucrose preference test (SPT), forced swimming test (FSW), and open-air test (OFT) were used to study depressive Although acupuncture therapy, as a preventive and therapeutic technique, is low or no risk for some cardiovascular diseases, its role in safeguarding myocardial hypertrophy (MH) has not been clarified. Therefore, this study focused on examining whether electroacupuncture (EA) can alleviate MH by up-regulating tryptophan 5-serotonin (5-HT) metabolism, depressive disorder, and gastrointestinal dysfunction in MH rat models. We evaluated the effect of EA on myocardial ischemia in the ISO-induced myocardial hypertrophy (MH) rat model. Forty Sprague – Dawley (SD) rats aged 3 months were randomly divided into normal group, model group, EA group, and sham EA group with 10 rats in each group. Heart weight/body weight ratio (HW/BW) and left ventricular weight/body weight ratio (LVW/BW) were used to evaluate the regression of MH. Cardiac pathology was evaluated by ultrastructural observation and hematoxylin and eosin (H&E) staining. Sucrose preference test (SPT), forced swimming test (FSW), and open-air test (OFT) were used to study depressive behavior. The gastric retention and intestinal transport were evaluated by carbon powder labeling and the expression of 5-HT in the cerebral cortex and ileum was detected by immunohistochemistry. Depression-like symptoms in rats can be relieved by EA therapy. For instance, the consumption rate of sucrose solution was higher, the total distance and central distance in the open field test were increased, and EA treatment could reduce the immobility time of these rats. Swimming, struggling and immobility latencies were also increased in the forced swimming test. After EA treatment, the expression of 5-HT in the cerebral cortex and ileum increased. Finally, we found that EA ameliorated ischemia, depression, and gastrointestinal dysfunction in ISO-induced MH rats, which may be related to 5-HT metabolism.
Highlights
Acupuncture therapy has been described as a preventive and therapeutic technique with low or no risk for a number of conditions related to cardiovascular disease
EA improved the ischemic and depressed symptoms, as well as gastrointestinal dysfunction of myocardial hypertrophy (MH) rats model induced by isoproterenol hydrochloride (ISO), which may related with 5-HT metabolism
The current study investigates the effects of electroacupucture (EA) attenuates MH by upregulating tryptophan 5-hydroxytryptamine (5-HT) metabolism, depressive disorder and gastrointestinal dysfunction in MH rats model
Summary
Acupuncture therapy has been described as a preventive and therapeutic technique with low or no risk for a number of conditions related to cardiovascular disease. Depression is a frequent psychiatric symptom among patients with MH [2] and it effects the prognosis of MH as an independent risk factor. Previous studies showed that MH has an influence on intestinal barrier integrity and somatic psychiatric symptoms (e.g., gastrointestinal symptoms, fatigue, poor appetite, and nausea) that reflects prognosis of the disease. It was demonstrated in the clinical studies that myocardial injury was reduced effectively by acupuncture pretreatment in patients with myocardial ischemia [3]. Most of 5-HT in the body is contained within gastrointestinal tract, and it is important for depression and gastrointestinal function
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