Abstract
AbstractBiomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film‐based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β‐sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3‐amino‐4‐hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier‐transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy‐energy dispersive X‐ray spectroscopy, thermogravimetric analysis, X‐ray diffraction, and X‐ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas‐Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.
Highlights
Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions
Silk-based biomaterials in a selection of materials morphologies have been prepared using the silk proteins produced by various species[8] and recombinantly,[5,6] as have composites including such proteins.[9,10]
The films were characterized by a variety of techniques (including circular dichroism (CD), Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), Raman spectroscopy, resistance measurements, scanning electron microscopyenergy dispersive X-ray spectroscopy (SEM-EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS)), as was the adhesion of fibroblasts to the films, and their ability to deliver a fluorescently labeled clinically relevant drug (Texas-Red Gentamicin) in vitro
Summary
Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions.
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