Abstract
Indolizine derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we report a novel electro-oxidative cascade cyclization reaction that uses electricity as the primary energy input to promote the reaction, leading to a series of heterocyclic substituted indolizine derivatives under exogenous-oxidant-free conditions. It is noteworthy that this electrochemical method provides a novel strategy for generating heterocyclic diversity of quinazolinones and quinolines on indolizines. In addition, the sole byproduct in the reaction was molecular hydrogen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have