Abstract
Electro-oxidation of aldehydes (R1R2CHCHO) and ketones (R1R2HCOR3) in methanol containing iodide ion (I–) and KOH gave the corresponding α-hydroxylated acetals [R1R2C(OH)CH(OMe)2 and R1R2C(OH)C(OMe)2R3, respectively] in good yields. The first step of this oxidation is explained in terms of the attack of an anodically generated active iodine species ‘I+’ on enols of R1R2CHCHO and R1R2CHCOR3. α-Hydroxy acetals were useful starting materials as exemplified by reaction with aniline or methyl carbamates in the presence of Lewis acids to afford β-keto amine derivatives. The anodic oxidation of α-hydroxy acetals was also carried out.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
