Abstract
Studies have shown that acupuncture is very effective in treating chronic stress depression. However, little is known about the therapeutic mechanism of electro-acupuncture. Metabolomics, on the other hand, is a technology that determines the metabolic changes of organisms caused by various interventions as a whole and is related to the overall effect of electro-acupuncture (EA). 1HNMR, serum sample analysis, and histopathology and molecular biology analysis were used to evaluate the effects of EA. The results show that electro-acupuncture points can regulate the heat pain threshold of chronic stress model rats and change the morphology of adrenal cortex cells Structure, and regulate the contents of corticotropin-releasing hormone, Corticosterone (CORT), glucose, alanine and valine in the samples. These findings help to clarify the therapeutic mechanism of electro-acupuncture on heterologous chronic stress model rats. The effect of electro-acupuncture on improving chronic stress is likely to be achieved by regulating glucose metabolism, which can provide a reference for clinical acupuncture treatment of chronic stress depression.
Highlights
Studies have shown that acupuncture is very effective in treating chronic stress depression
A significant difference in body weight and thermal pain threshold was observed between groups following 9 days of heterotypic intermittent stress (HIS)
The body weight and thermal pain threshold significantly decreased in the model group compared with the control group (p < 0.05)
Summary
Studies have shown that acupuncture is very effective in treating chronic stress depression. The results show that electro-acupuncture points can regulate the heat pain threshold of chronic stress model rats and change the morphology of adrenal cortex cells Structure, and regulate the contents of corticotropin-releasing hormone, Corticosterone (CORT), glucose, alanine and valine in the samples. The effect of electro-acupuncture on improving chronic stress is likely to be achieved by regulating glucose metabolism, which can provide a reference for clinical acupuncture treatment of chronic stress depression. It can be characterised in a timely and sensitive m anner[11,12] This provides a good technical means for us to study the mechanism of chronic stress and the intervention effect of electro-acupuncture. The heterotypic intermittent stress (HIS) model was selected because of its unpredictable factors that make it difficult for rats to adapt to stressors
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