Abstract
To evaluate the possible beneficial effects of electro-acupuncture in rats subjected to ketamine/xylazine (KX) intra-peritoneal (i.p.) anesthesia. Forty-eight male Wistar rats were distributed in four equal groups. All rats received i.p. injections of ketamine (90 mg/kg) +xylazine (10 mg/kg) anesthesia. Basal values group (control) rats (BV) received no additional treatment. The equivalent of the human right ST36 (Zusanli) and CV-12(Zhongwan) acupoints were chosen for needling and electrical stimulation. AC rats were needled with sterilized disposable stainless steel needles at right ST36 and CV12 acupoints; needles were retained for 30 minutes. EAC10 rats, after needle insertion as described, had electrodes connected to both needles and to an electro stimulator model NKL EL-608; pulsed square waves, 10 Hz, 10 mA, was applied for 30 minutes. EAC100 rats were submitted to EA as described. However, a greater frequency (100 Hz) was used. Thirty-seven rats remained under adequate anesthetic level during the experiment. However, maintenance anesthesia was required by 11 rats. Need for additional anesthesia decreased to 9.1% in EAC100 rats compared to BV (36.3%). Both the AC and the EAC10/100 prolong the anesthetic effect of the combination Ketamine-xylazine in rats, allowing longer duration of anesthesia with a lower dose of anesthetic, thereby reducing the occurrence of complications.
Highlights
Acupuncture (AC) is one of the main forms of treatment in traditional Chinese Medicine
The identification of brain regions associated with acupuncture analgesia in animal experiments has been confirmed in the human brain by the use of sophisticated examination techniques, such as functional magnetic resonance imaging[5]
The equivalent of the human right ST36 (Zusanli) and CV-12 (Zhongwan) acupoints were chosen for needling and electrical stimulation
Summary
Acupuncture (AC) is one of the main forms of treatment in traditional Chinese Medicine. It involves the use of sharp, thin needles that are inserted in the body at very specific points[1]. Electroacupuncture (EAC) is a modification of this technique where small electrical currents are applied to needles previously inserted in the body and appears to have more consistently reproducible results in many specific clinical and research settings[2,3,4]. The identification of brain regions associated with acupuncture analgesia in animal experiments has been confirmed in the human brain by the use of sophisticated examination techniques, such as functional magnetic resonance imaging[5]
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