Abstract

Biliary Atresia (BA) is a severe liver disease that affects newborns. This disease may cause cholestasis and progressive hepatic failure or even death if not treated immediately. ELISA blood tests for metabolic screening are the current method of diagnosing BA. However, Newborns need rapid BA detection for treatment in the future. Level increase of intrahepatic matrix metalloproteinase-7 (MMP7) is a factor known to cause BA-related liver fibrosis. We brought out a platform to detect BA using an electric-double-layer (EDL)-gated field-effect transistor (FET). MMP7 concentration differences affect gate voltages then consequent in the sensitivity of this platform. EDL-gated FETs are planned to display in hospitals for medical personnel to accurately detect BA in infants.

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