Abstract
Electric and magnetic stimulation play a unique role in promoting bone regeneration. Here, a novel type of electrically-magnetically bifunctional polymethyl methacrylate (PMMA) composite that integrates stimulus-responsive, cytocompatiablity and osteostimulation properties were developed by incorporating activated carbon nanotubes (ACNTs) into PMMA matrix. The maximum hyperthermal temperature of polymerization (Tmax), physicochemical properties and cytocompatibility of the PMMA composites were evaluated. The results showed that the ACNTs-doped PMMA composite exhibited a dramatic reduced Tmax, effectively alleviating the adverse effect of the strongly exothermic polymerization of PMMA, an enhanced compressive strength, a reduced elastic modulus being close to human spongy bone, certain conductivity and magnetic character. The cell culture indicated that the PMMA composite with 6 wt% ACNTs had better cell viability under the 10 mA of electrical stimulation (ES), 60 mT of static magnetic field stimulation (SMF), and these combination. This electrically-magnetically bifunctional PMMA composite with excellent stimulus-responsive, mechanical properties and cytocompatiablity has great practical potential for bone tissue engineering.
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