Abstract
We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher–Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation.
Highlights
The modeling of cardiac electrical function is a well-established area of research that began with early models of cardiac cells developed by D
Sudden cardiac death is a result of cardiac arrhythmias that occur in the ventricles of the human heart [2]
In a previous article [27], we described an axisymmetric model of the left ventricle (LV) of the human heart
Summary
The modeling of cardiac electrical function is a well-established area of research that began with early models of cardiac cells developed by D. We show that the scroll waves drift and we calculate their drift velocity and period of rotation depending on the fiber rotation angle and the diffusion coefficients ratio.
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