Abstract
To investigate a neuronal mechanism controlling heat production of brown adipose tissue (BAT), ventral regions of the lower midbrain was stimulated by rectangular electric current (0.1 ms, 1 mA, 5–50 Hz) while recording temperatures of the interscapular BAT (IBAT), rectum and arterial blood pressure in urethane-anesthetized Wistar rats at room temperature of 24–26°C. Unilateral stimulation (10 Hz) for 5 min to the midbrain around the retrorubral field decreased temperatures of IBAT (0.33±0.03°C, n=33) and rectum (0.10±0.01°C). The response was reversed when procaine (10%, 800 nl) was injected into the same locus. The results support the hypothesis that a tonic inhibitory mechanism for metabolic heat production locates around the retrorubral field.
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