Abstract
The role of the claustrum in consciousness and vigilance states was proposed more than two decades ago; however, its role in anesthesia is not yet understood, and this requires more investigation. The aim of our study was to assess the impact of claustrum electrical stimulation during isoflurane anesthesia in adult rats. The claustrum in the left hemisphere was electrically stimulated using a bipolar tungsten electrode inserted stereotaxically. In order to monitor the anesthetic depth, the electrocorticogram (ECoG) was recorded before, during, and after claustrum stimulation using frontal and parietal epidural electrodes placed over the left hemisphere. After reaching stabilized slow-wave isoflurane anesthesia, twenty stimuli, each of one second duration with ten seconds interstimulus duration, were applied. ECoG analysis has shown that, after a delay from the beginning of stimulation, the slow-wave ECoG signal changed to a transient burst suppression (BS) pattern. Our results show that electrical stimulation of the claustrum area during slow-wave isoflurane anesthesia induces a transitory increase in anesthetic depth, documented by the appearance of a BS ECoG pattern, and suggests a potential role of claustrum in anesthesia.
Highlights
IntroductionRecent studies have revealed that this structure interacts with almost all other structures of the brain: motor cortex, somatosensory cortex, prefrontal cortex, cingulate cortex, auditory and visual cortex, hippocampus, amygdala, and caudate nucleus [2]
The claustrum is a subcortical structure of the brain, first described by Thomas Willis in 1672 [1].Recent studies have revealed that this structure interacts with almost all other structures of the brain: motor cortex, somatosensory cortex, prefrontal cortex, cingulate cortex, auditory and visual cortex, hippocampus, amygdala, and caudate nucleus [2]
In order to investigate the potential role of the claustrum in anesthesia, we evaluated the effect of claustral stimulation on depth of anesthesia in isoflurane-anesthetized rats
Summary
Recent studies have revealed that this structure interacts with almost all other structures of the brain: motor cortex, somatosensory cortex, prefrontal cortex, cingulate cortex, auditory and visual cortex, hippocampus, amygdala, and caudate nucleus [2]. In 2014, Koubeissi et al noticed that left claustrum stimulation in humans resulted in the abolition of consciousness for the whole duration of stimulation [5]. In a recent study, Bickel and Parvizi reported that bilateral stimulation of the claustrum in humans failed to induce a loss of consciousness [6]. One major aspect to be considered when comparing the two studies is that the protocol used by Bickel and Parvizi [6] was fairly different from the one presented by Koubeissi et al [5]. In 2015 Chau et al studied a group of
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
