Abstract
The two-dimensional cable analysis for flat epithelia was made suitable for the study of current and voltage distribution in cylindrical epithelia which are assumed to have low paracellular shunt resistance. Applying the solutions to the proximal tubule of the doubly perfused volume-expanded Necturus kidney, the sum of cell membrane conductances in parallel, (g+g′), was determined and found to be 0.56 mmho/cm2. From this figure, the theoretical upper limit for the sum of membrane conductances in series may be estimated at 0.14 mmho/cm2, though a figure of 0.105 mmho/cm2 appears more realistic for this limit (membrane resistance in series equal to or greater than 9500 ohm·cm2). The core resistanvity, ϱ, of the proximal cell column was 11100 ohm·cm. When the kidney was perfused with sodium benzene sulfonate, choline chloride or LiCl, the figures for (g+g′) and ϱ were 0.48 mmho/cm2 and 15360 ohm·cm, 0.67 mmho/cm2 and 55600 ohm·cm and 0.40 mmho/cm2 and 4630 ohm·cm respectively.
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