Abstract
Neurons possess multiple types of voltage-dependent calcium channels. These channels are classified as either low-voltage-activated (LVA/T-type) or high-voltage-activated (HVA) consisting of L, N, P, Q and R subtypes. T-type Ca channels can be opened by small depolarization that are under the threshold for action potential generation. These T-type Ca channels may be involved in the sub threshold depolarizations that underlies neuronal bursting activities in neurons. Such burst firing might originate in the postsynaptic membrane of the neuronal dendrites.
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