Abstract
The application of electric field to graft materials has significant contribution in bone healing mechanism. Hence, the aim of this study is to develop conductive hydroxyapatite (HAp) scaffolds by introducing different concentrations of silver ion into its structure and demonstrate its impact on in vitro bioactivity and electrical properties. Hydroxyapatite was synthesized by wet chemical method and calcium ions from HAp structure have been partially replaced by silver ions. The HAp and Ag-HAp nanocomposites were characterized by Fourier-transform infrared, Raman spectroscopy, XRD and EDAX for functional group and phase formation analysis as well as to confirm existence of silver ions in HAp structure respectively. Bioactivity of these scaffolds was assessed by using simulated body fluid. The surface morphology, structural analysis and electrical properties of scaffolds before and after formation of newly calcified tissues on its surface were examined via scanning electron microscopy (SEM), XRD, FTIR, dielectric and impedance spectroscopy techniques. Overall, our finding suggests that the administration of silver ions in HAp scaffold boosts bioactivity and has strong correlation with electrical properties.
Highlights
Bone loss is major concern worldwide due to several reasons such as accidents, bone diseases like osteoporosis, bone tumor as a consequence bone turns to be fracture
Hydroxyapatite was synthesized by wet chemical method and calcium ions from HAp structure have been partially replaced by silver ions
The surface morphology, structural analysis and electrical properties of scaffolds before and after formation of newly calcified tissues on its surface were examined via scanning electron microscopy (SEM), XRD, Fourier transform infrared (FTIR), dielectric and impedance spectroscopy techniques
Summary
Bone loss is major concern worldwide due to several reasons such as accidents, bone diseases like osteoporosis, bone tumor as a consequence bone turns to be fracture. Hydroxyapatite [Ca10(PO4)6(OH), abbreviated as HAp], being bioactive and biocompatible, can be an exciting material in emerging field of synthetic bone graft due to its chemical similarity with the mineral part of the human bone [1] [2] [3]. The immense research has been explored in modification of HAp structure by substituting metal ion species like copper (Cu2+), manganese (Mn2+), silicon (Si4+), iron (Fe3+), strontium (Sr2+), cobalt (CO2+), zinc (Zn2+), silver (Ag+) for improvement in its biological premises for specific applications in biomedical field [8]-[15]. The inclusion of silver ions in HAp structure promotes bioactivity and such coating on metal offers corrosion resistance [18] [19] [20]. The cation exchange rate of HAp is found to be very high with silver ions
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