Electrical neuroimaging of early sensory processing in first-episode psychosis

Abstract

Event Abstract Back to Event Electrical neuroimaging of early sensory processing in first-episode psychosis Jean-François Knebel1*, Lucas Spierer1, Philippe Baumann1, Carina Ferrari1, Andrea Polari1, Tanja Teichmann1, Kim Q. Do1, Philippe Conus1 and Micah M. Murray1 1 CHUV/UNIL, Switzerland Low-level, early auditory and visual impairments have been documented in patients with schizophrenia and their first-degree relatives. More recently, such findings have been extended to first-episode psychotics. At present, it remains under-determined the precise mechanism leading to these impairments, including but not limited to whether any impairments reflect general sensory processing deficits or specific functional deficits in processing particular stimulus properties, as well as whether impairments in one sensory modality are co-occur with those in another sensory modality. We performed electrical neuroimaging analyses of event-related potentials recorded from 16 (all males; 13 right-handed) first-episode psychosis patients and 14 (10 males; 12 right-handed) age-matched controls. The visual task entailed the presentation of Kanizsa-type illusory contour stimuli, allowing for the parallel investigation of impairments in visual sensory processing and completion processes. The auditory task entailed an oddball paradigm. The frequent stimulus (70% of trials) was a 1000Hz centrally-presented sound of 100ms duration. The infrequent stimuli (10% of trials each) varied in pitch (1200Hz), perceived lateralization (700µs), or duration (150ms) Remaining parameters matched the frequent stimulus. While we were able to replicate prior findings of impaired early visual responses in first-episode patients using analyses of individual scalp electrodes, this was not evident in analyses of global features of the electric field. By contrast, there was evidence for sensory and functional auditory processing impairments at all levels of analysis. We discuss our findings in the context of attempts to establish biomarkers of psychosis. Funding: NCCR “SYNAPSY”-National Science Foundation (n° 51AU40_125759)- the SNF (to MMM)-the Leenaards Foundation-the Loterie Romande. Keywords: Auditory and visual impairments, Perception Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Poster Sessions: Neurophysiology of Sensation and Perception Citation: Knebel J, Spierer L, Baumann P, Ferrari C, Polari A, Teichmann T, Do KQ, Conus P and Murray MM (2011). Electrical neuroimaging of early sensory processing in first-episode psychosis. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00478 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Nov 2011; Published Online: 28 Nov 2011. * Correspondence: Dr. Jean-François Knebel, CHUV/UNIL, Lausanne, Switzerland, jean-francois.knebel@chuv.ch Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jean-François Knebel Lucas Spierer Philippe Baumann Carina Ferrari Andrea Polari Tanja Teichmann Kim Q Do Philippe Conus Micah M Murray Google Jean-François Knebel Lucas Spierer Philippe Baumann Carina Ferrari Andrea Polari Tanja Teichmann Kim Q Do Philippe Conus Micah M Murray Google Scholar Jean-François Knebel Lucas Spierer Philippe Baumann Carina Ferrari Andrea Polari Tanja Teichmann Kim Q Do Philippe Conus Micah M Murray PubMed Jean-François Knebel Lucas Spierer Philippe Baumann Carina Ferrari Andrea Polari Tanja Teichmann Kim Q Do Philippe Conus Micah M Murray Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.