Abstract
We present data concerning the electrical properties of a class of biosensor devices based onbio-functionalized solid state nanopores able to detect different kinds of interactionsbetween probe molecules, chemically attached to the pore surface, and target moleculespresent in solution and electrophoretically drawn through the nanometric channel. Thegreat potentiality of this approach resides in the fact that the functionalization of aquite large pore (up to 50–60 nm) allows a sufficient diameter reduction for theattainment of a single molecule sensing dimension and selective activation, withoutthe need for further material deposition, such as metal or oxides, or localizedsurface modification. The results indicate that it will be possible, in the nearfuture, to conceive and design devices for parallel analysis of biological samplesmade of arrays of nanopores differently functionalized, fabricated by standardlithographic techniques, with important applications in the field of moleculardiagnosis.
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