Electrical Brain Stimulation

Abstract

s / Brain Stimulation 8 (2015) 428e437 437 implanted in the subthalamic nucleus (STN) in the past 15 years has helped in clarifying basal ganglia pathophysiology and its relation to PD symptoms. LFP-clinical correlations should provide the rationale for developing and implementing a new aDBS devices able to adapt stimulation parameters to the individual patient’s needs using LFPs as feedback (Priori et al., 2012, Exp Neurol). We tested the external portable device aDBS in 6 freely moving PD patients after DBS electrodes implant in STN and we compared its clinical efficacious to that of cDBS. The 5th and the 6th day after the DBS electrodes implant, the patients, after the standard antiparkinsonian medication, underwent two hours of cDBS and two hours of aDBS, respectively. The patients were not aware of the DBS type. The motor state was evaluated by two blinded neurologists through the Unified Parkinson’s Disease Rating Scale (UPDRS) motor scale (part III), and Rush dyskinesia rating scale (DRS). From a technological point of view the device confirmed its ability to adapt stimulation to LFPs. Whereas the mean UPDRS III score was the same during aDBS and cDBS, the dyskinesias were less severe, both standing and walking. Our portable device unlocks new opportunities to study aDBS in freely moving PD patients providing new insights into the impact of this novel technology on their quality of life.